Protein Folding Diseases

Group: 4 #group-4

Relations

  • Ubiquitin-Proteasome System: The ubiquitin-proteasome system is responsible for degrading misfolded and damaged proteins.
  • Chaperone Proteins: Chaperone proteins assist in the proper folding of proteins and can help prevent protein misfolding.
  • Protein Quality Control: Protein quality control mechanisms, such as chaperones and degradation pathways, are crucial for preventing protein folding diseases.
  • Misfolded Proteins: Protein folding diseases are caused by the misfolding and aggregation of specific proteins.
  • Neurodegeneration: Many protein folding diseases, such as Alzheimer’s and Parkinson’s, are characterized by neurodegeneration.
  • Amyloidosis: Amyloidosis is a group of protein folding diseases characterized by the deposition of misfolded proteins in various tissues.
  • Parkinson’s Disease: Parkinson’s disease is a protein folding disease caused by the misfolding and aggregation of the alpha-synuclein protein.
  • Autophagy: Autophagy is a cellular process that can degrade misfolded protein aggregates.
  • Protein Homeostasis: Protein folding diseases disrupt protein homeostasis, the balance between protein synthesis, folding, and degradation.
  • Alzheimer’s Disease: Alzheimer’s disease is a protein folding disease caused by the misfolding and aggregation of the amyloid-beta and tau proteins.
  • Prion Diseases: Prion diseases, such as Creutzfeldt-Jakob disease, are caused by the misfolding and aggregation of prion proteins.
  • Protein Trafficking: Misfolded proteins can disrupt protein trafficking pathways, leading to cellular dysfunction.
  • Huntington’s Disease: Huntington’s disease is a protein folding disease caused by the misfolding and aggregation of the huntingtin protein.