Protein Folding Diseases
Group: 4 #group-4
Relations
- Ubiquitin-Proteasome System: The ubiquitin-proteasome system is responsible for degrading misfolded and damaged proteins.
- Chaperone Proteins: Chaperone proteins assist in the proper folding of proteins and can help prevent protein misfolding.
- Protein Quality Control: Protein quality control mechanisms, such as chaperones and degradation pathways, are crucial for preventing protein folding diseases.
- Misfolded Proteins: Protein folding diseases are caused by the misfolding and aggregation of specific proteins.
- Neurodegeneration: Many protein folding diseases, such as Alzheimer’s and Parkinson’s, are characterized by neurodegeneration.
- Amyloidosis: Amyloidosis is a group of protein folding diseases characterized by the deposition of misfolded proteins in various tissues.
- Parkinson’s Disease: Parkinson’s disease is a protein folding disease caused by the misfolding and aggregation of the alpha-synuclein protein.
- Autophagy: Autophagy is a cellular process that can degrade misfolded protein aggregates.
- Protein Homeostasis: Protein folding diseases disrupt protein homeostasis, the balance between protein synthesis, folding, and degradation.
- Alzheimer’s Disease: Alzheimer’s disease is a protein folding disease caused by the misfolding and aggregation of the amyloid-beta and tau proteins.
- Prion Diseases: Prion diseases, such as Creutzfeldt-Jakob disease, are caused by the misfolding and aggregation of prion proteins.
- Protein Trafficking: Misfolded proteins can disrupt protein trafficking pathways, leading to cellular dysfunction.
- Huntington’s Disease: Huntington’s disease is a protein folding disease caused by the misfolding and aggregation of the huntingtin protein.